Central Department of Physics, Tribhuvan University, Kathmandu, Nepal

Invited Speakers

Physics in the 21st Century – A personal Perspective

Abstract:

In this presentation I will present major achievements up till now and my personal view on major problems and possible future directions in physics. In my personal opinion I will describe king of physics – Astrophysics and Cosmology, the queen – high energy particle physics, and the subjects – all other parts of physics. 

 Sitaram Byahut, PhD
Sitaram Byahut, PhDInvited Speaker

Developing Curiosity of Performing Experiments

Abstract:

Science has tremendous role in the development of the modern age. There are at least two pillars of the science namely: theory and experiment. Both help each other to test their validity and for the creation of another new one. In addition, high speed capacity computers have emerged computational field of research that many people are involved in present days. 

Hari Lamichhane, PhD
Hari Lamichhane, PhDInvited Speaker

No matter how many models and theories are developed, they will be incomplete unless they are tested experimentally. It means that a theory merely predicts the nature with some limited frameworks. That is, there are many phenomena going on in the nature which can be explored by performing appropriate experiments. Though much tedious and expensive job is the experimental research in comparison to the theoretical and computational research, it is essential to develop efficient devices or material products. Therefore, attracting young scientists towards experimental research is one of the major problems which can be solved through motivating them by highlighting the beauty of experiments towards learning the nature.

Please look below for detailed schedule.


Date/Time:
ET:      2023-07-14 23:15:00
Nepal: 2023-07-15 09:00:00

Abstract Number: ANPA2023-N00045

Presenting Author: Sitaram Byahut (Invited)

Presenter's Affiliation: Central Department of Physics, Nepal

Title: Physics in the 21st Century – A personal Perspective

Location: Central Department of Physics, T.U., Nepal

Show/Hide Abstract

In this presentation I will present major achievements up till now and my personal view on major problems and possible future directions in physics. In my personal opinion I will describe king of physics – Astrophysics and Cosmology, the queen – high energy particle physics, and the subjects – all other parts of physics.

Date/Time:
ET:      2023-07-14 23:45:00
Nepal: 2023-07-15 09:30:00

Abstract Number: ANPA2023-N00044

Presenting Author: Hari Prasad Lamichhane (Invited)

Presenter's Affiliation: Central Department of Physics, Nepal

Title: Developing Curiosity of Performing Experiments

Location: Central Department of Physics, T.U., Nepal

Show/Hide Abstract

Science has tremendous role in the development of the modern age. There are at least two pillars of the science namely: theory and experiment. Both help each other to test their validity and for the creation of another new one. In addition, high speed capacity computers have emerged computational field of research that many people are involved in present days. No matter how many models and theories are developed, they will be incomplete unless they are tested experimentally. It means that a theory merely predicts the nature with some limited frameworks. That is, there are many phenomena going on in the nature which can be explored by performing appropriate experiments. Though much tedious and expensive job is the experimental research in comparison to the theoretical and computational research, it is essential to develop efficient devices or material products. Therefore, attracting young scientists towards experimental research is one of the major problems which can be solved through motivating them by highlighting the beauty of experiments towards learning the nature.

Date/Time:
ET:      2023-07-15 00:15:00
Nepal: 2023-07-15 10:00:00

Abstract Number: ANPA2023-N00094

Presenting Author: Binil Aryal (Invited)

Presenter's Affiliation: Central Department of Physics, Tribhuvan University, Nepal

Title: Research Publication of Tribhuvan University: 1998 to 2022

Location: Central Department of Physics, T.U., Nepal

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An analysis of research publications of Tribhuvan University in the last 25 years (1998-2022) will be presented and discussed. A comparison will be made with the annual publication rate of TU and Delhi University, Jawahar Lal Nehru University, India Innsbruck University, Austria, and Clemson University, USA for the same period. In addition, strengths, weaknesses, and challenges concerning interdisciplinary and multidisciplinary research outcomes of TU will be interpreted. Finally, a connection between the citations of articles published by the TU family and the Times Higher Education World University ranking of TU will be discussed. _x000D_

Date/Time:
ET:      2023-07-15 01:15:00
Nepal: 2023-07-15 11:00:00

Abstract Number: ANPA2023-N00027

Presenting Author: Anjan Dahal

Presenter's Affiliation: Central Department of Physics, Tribhuvan University, Kathmandu, Nepal

Title: Stopping Sites and Charge States of Muon in Azurin, Copper Protein

Location: Central Department of Physics, T.U., Nepal

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Protein-mediated electron-transfer (ET) reactions are essential for converting energy in processes such as photosynthesis and respiration. For better understanding of the biological process, study of the ET mechanism is very important. Pioneered by K. Nagamine et al., ET in Cytochrome c protein [1], and DNA [2] reported using positive muon. To understand the muon experiment data, AD Pant et. al studied muon sites and charge state in amino acids and peptide bonds using first-principles calculations [3,4]. To understand ET in protein, we perform a systematic study to find stopping sites and charge states of muon in Azurin, Copper Protein. Due to the complexity of biological system in geometry and dynamics, we have selected Azurin, which is a relatively small protein with copper as a single active site. We perform geometry optimization of structure and theoretical calculations using hybrid density functional (B3LYP/6-31G(d) and 6-31G(d,p)) in Gaussian 09 set of programs. Also, natural population analysis and electrostatic potential analysis helps to find the charge states and electronegative sites in the protein. Outcome of the research will provide valuable insights into the biochemistry and ET process in azurin and other big proteins. In the program, the stopping sites and charge states of muon in azurin will be presented. References [1] K. Nagamine et at., Physica B: Condensed Matter, 289 (2000) 631–635. [2] E. Torikai et al., Hyperfine Interactions 138 (2001) 509–514. [3] A. D. Pant et al., JPS Conf. Proc., 21 (2018) 011038. [4] A. D. Pant et al., JPS Conf. Proc., 25 (2019) 011013.

Date/Time:
ET:      2023-07-15 01:30:00
Nepal: 2023-07-15 11:15:00

Abstract Number: ANPA2023-N00028

Presenting Author: Anup Shrestha

Presenter's Affiliation: Central Department of Physics, Tribhuvan University, Kathmandu, Nepal

Title: Dose estimation for muon to develop non-invasive muon method for detection of hypoxia in tumor

Location: Central Department of Physics, T.U., Nepal

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Hypoxia, the region with low oxygen concentration in the tissue[1] is an important factor for tumor treatment. Since hypoxia causes resistance to the treatment [2], its detection is the foremost step towards the treatment process. Even though there are several existing methods to detect hypoxia, they come with limitations due to the requirement of special conditions and mainly due to invasive nature [3-5]. Instead, the newly proposed muon method does not require those special conditions and it is non-invasive in nature too, which is a great advantage over the currently existing methods[3,4]. Muon like a light proton, is more sensitive due to higher magnetic moment. Muonium, a bound state of muon and electron, is like a light isotope of hydrogen atom. In the proposed muon method, muonium undergoes spin exchange interaction with molecular oxygen to provide information about oxygen content in tumor tissue [3]. It is important to find the amount of muon beam dose to be used for the practical applications. Hence, we study the energy, intensity and profile (size) of the beam at various concentrations and sizes of the tumor. The estimated muon beam profile and energy using Monte Carlo simulation will be present in the program. References [1] W. C. Wilson and B. Shapiro, Anesthesiology Clinics of North America, 19 (2001) 769–812. [2] P. Vaupel and L. Harrison, The oncologist, 9 (2004) 4–9. [3] A. D. Pant et. al., Nuclear Instruments and Methods in Physics Research A, 1011 (2021) 165561. [4] A. Pant et. al., Journal of Physics: Conference Series, 551 (2014) 012043. [5] S. Chopra et. al., International journal of radiation biology, 85 (2009) 805–813.

Date/Time:
ET:      2023-07-15 01:45:00
Nepal: 2023-07-15 11:30:00

Abstract Number: ANPA2023-N00029

Presenting Author: Bidhya Thapa

Presenter's Affiliation: Central Department of Physics, Tribhuvan University, Kathmandu, Nepal

Title: Insights on the Interactions of Kaiso with p120 catenin from Molecular Simulations

Location: Central Department of Physics, T.U., Nepal

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Protein-Protein interactions are crucial for the regulation of various cellular and biological processes. Molecular level insights on the interaction of Zinc finger (ZF) protein Kaiso with its binding partner p120 catenin are essential because of their role in development and cancers. Despite their important biological role, there is no structural characterization of the Kaiso-p120 catenin complex. In this work, we first modeled the optimum complex between Kaiso and p120 catenin through molecular docking and employed molecular dynamics (MD) simulations to investigate the structural features of this complex. Our MD simulation results show that the non contiguous 5’- and 3’- flanking regions of ZF domains in Kaiso interact with the 1-7 arm repeats of p120 catenin. The root mean square deviation (RMSD) measurements from the 500 ns of the MD simulation time reveal the stability of the Kaiso-p120 catenin complex. In addition, we identified the major interacting residues involved in the binding of these two proteins. Furthermore, we explored various non-covalent interactions such as; hydrogen bonds, salt-bridges, as well as hydrophobic interactions that are responsible for the complex formation and stabilization.

Date/Time:
ET:      2023-07-15 02:00:00
Nepal: 2023-07-15 11:45:00

Abstract Number: ANPA2023-N00046

Presenting Author: Chhabi Lal Gnawali

Presenter's Affiliation: Department of Applied Sciences and Chemical Engineering, Pulchowk Campus, Institute_x000D_ of Engineering (IOE), Tribhuvan University, Lalitpur, Nepal

Title: Hierarchically Porous Carbon Materials from Phyllanthus emblica Seed Stones as the Electrode Materials for the High-Performance Supercapacitors

Location: Central Department of Physics, T.U., Nepal

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High surface area nanoporous activated carbon materials synthesized from natural carbon sources such as biowaste with large porosity and well-defined pore structures are preferred as electrode materials for high-performance supercapacitors. Here we report the fabrication of novel nanoporous activated carbon material from Phyllanthus emblica (Amala) seed stones by the chemical activation using potassium hydroxide (KOH) as an activator at different carbonization temperatures (700-1000 °C) under the nitrogen gas atmosphere. The precursor and the prepared carbon materials were characterized by the thermogravimetric analysis (TGA), Fourier transform-infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Raman scattering, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Nitrogen adsorption-desorption isotherms estimated the specific surface area, pore size distribution, and average pore size. The total specific surface area ranges from 1360 to 1946 m2 g-1, and the total pore volume ranges from 0.664 to 1.328 cm3 g-1. The electrochemical energy storage performance was studied by cyclic voltammetry (CV), galvanostatic charge/discharge (GCD), and electrochemical impedance spectroscopy (EIS) in an aqueous 1 M sulfuric acid (H2SO4) solution in a three-electrode cell set up. The specific capacitance of the sample with best surface area was found to be 272 F g-1 at a current density of 1 A g-1 followed by 60% capacitance retention at a high current density of 50 A g-1. Additionally, the electrode showed outstanding cycle performance of 98 % after 10,000 charging/discharging cycles. These results indicate that the prepared nanoporous activated carbon material from Phyllanthus emblica seed stones led to the excellent supercapacitor electrode material for high-energy-storage supercapacitor applications. Keywords: Phyllanthus emblica seed, KOH activation, nanoporous activated carbon, electrochemical measurement, supercapacitor

Date/Time:
ET:      2023-07-15 02:15:00
Nepal: 2023-07-15 12:00:00

Abstract Number: ANPA2023-N0006

Presenting Author: Keshab Chaudhary

Presenter's Affiliation: Central Department of Physics, Tribhuvan University

Title: A Study of Dust Properties nearby Pulsar PSRJ0856-6137 Using Iris and Akari Surveys

Location: Central Department of Physics, T.U., Nepal

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We have conducted a detailed analysis of the dust structure around PSR J0856-6137 in the far infrared band by using Sky View Virtual observatory in two surveys: IRIS (60 μ m and 100μ m) and AKARI (90μm  and 140μm) survey. We have studied different physical properties such as dust color temperature, dust mass, and Planck’s function. The maximum and minimum temperature was found to be 24.815 ± 0.008K, 23.899 ± 0.008K and 27.759 ± 0.016K, 26.178 ± 0.016K in the IRIS and the AKARI surveys respectively. In both cases, the offset temperature was obtained less than 2 k. The average dust mass was found to be 1.341×1027 kg and 1.460 ×1025 kg in the IRIS and the AKARI surveys respectively. We found a small offset temperature, which suggests that the system is in a state of thermal equilibrium. We conducted a comparison of these physical parameters and found similar results to those of earlier research. This research can aid in comprehending the evolution of the pulsar.

Date/Time:
ET:      2023-07-15 02:30:00
Nepal: 2023-07-15 12:15:00

Abstract Number: ANPA2023-N0007

Presenting Author: Lok Nath Sharma

Presenter's Affiliation: Patan Multiple Campus, IOST, Tribhuvan University, Nepal

Title: Variation in Horizontal components of the Geomagnetic Field at Middle and Low latitudes during the Solar storm of 23rd April 2023

Location: Central Department of Physics, T.U., Nepal

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Magnetic reconnection between Interplanetary Magnetic field (IMF) and magnetosphere allows solar wind to penetrate into Earth, generating geomagnetic storms. In this work, we investigate the effects of the storm of 23rd April 2023 into middle and low latitudes using geomagnetic field data from 5 Intermagnet ground stations. We look for possible connection with physical parameters from OMNIWeb data at 1-min resolution through cross-correlation analyses. The horizontal components of the Earth’s magnetic field show correlation with IMF parameters (By and Bz) of 0.72 and 0.96, respectively, with a time-lag up to 20 minutes, depending on station. Keywords: Interplanetary magnetic field (IMF), solar wind, cross correlation, magnetosphere, horizontal components of the Earth’s magnetic field

Date/Time:
ET:      2023-07-15 03:45:00
Nepal: 2023-07-15 13:30:00

Abstract Number: ANPA2023-N00026

Presenting Author: Narayan Gautam

Presenter's Affiliation: Central Department of Physics, Kirtipur, Nepal

Title: Molecular dynamics simulations-based investigation of HDAC7-MEF2A molecular interactions

Location: Central Department of Physics, T.U., Nepal

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Molecular dynamics simulations-based investigation of HDAC7-MEF2A molecular interactions Narayan Gautam1, Prem P. Chapagain2, Narayan P. Adhikari1, and Purushottam B. Tiwari3 Affiliations: 1Tribhuvan University, Kathmandu, Nepal; 2Florida International University, Mi-ami, FL, USA; 3Georgetown University, Washington, D.C., USA Corresponding Email: chapagap@fiu.edu; narayan.adhikari@cdp.tu.edu.np; pbt7@georgetown.edu Abstract Interactions between histone deacetylase 7 (HDAC7) and myocyte enhancer factor 2 (MEF2) regulate MEF2 activity. In the past, experimental studies were carried out for the interactions between these proteins and determined range of amino acids that are responsible for interactions. Despite prior experimental studies, to the best of our knowledge, there are no investigations characterizing the complex formation leading to identification of amino acid residues. In this study, we first modelled the HDAC7-MEF2A complex using AlphaFold and then conducted molecular dynamics (MD) simulations of the complex. Our analysis of MD simulations trajectories explored key amino acid residues that are involved in the complex formation through different interactions.

Date/Time:
ET:      2023-07-15 04:00:00
Nepal: 2023-07-15 13:45:00

Abstract Number: ANPA2023-N00017

Presenting Author: Num Prasad Acharya

Presenter's Affiliation: Ph.D. scholar

Title: Dust charging and ion flow at sheath boundary for active magnetized dusty plasma in the presence of q-nonextensive electron distribution

Location: Central Department of Physics, T.U., Nepal

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We have investigated the evolution of dust charge and ion flow at the sheath boundary for the collisional magnetized dusty plasma in the presence of non-Maxwellian electron distribution in account of source and sink terms. The set of governing fluid equations have been solved for given initial conditions, whereas the dust charging equation have been solved using Newton-Raphson method. We have extended the Bohm sheath condition for dusty plasma using Sagdeev potential approach and it is found that gas pressure, obliqueness of magnetic field, ion loss term, and choice of electron distribution affect the evolution of dust charge and flow of positive ions at the sheath boundary.

Date/Time:
ET:      2023-07-15 04:15:00
Nepal: 2023-07-15 14:00:00

Abstract Number: ANPA2023-N00020

Presenting Author: Pradeep Karki

Presenter's Affiliation: Tribhuvan University

Title: EFFECT OF ELECTRON IMPACT IONIZATION SOURCE TERM ON MAGNETIZED PLASMA SHEATH

Location: Central Department of Physics, T.U., Nepal

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EFFECT OF ELECTRON IMPACT IONIZATION SOURCE TERM ON MAGNETIZED PLASMA SHEATH Pradeep Karki1*, Suresh Basnet1,2, and Raju Khanal2 1Department of Physics, GoldenGate International College, Tribhuvan University, Kathmandu 44600, Nepal 2Central Department of Physics, Tribhuvan University, Kirtipur, Kathmandu 44613, Nepal Email: stonermind12@gmail.com In this study, a fluid model has been used to explore the magnetized plasma sheath properties in the presence of ion-neutral collision and electron impact ionization source term. To solve the set of fluid equations, the initial conditions at the sheath edge and physical parameters are used. The obtained results reveal that the ionization source term affects the plasma sheath parameters: electric potential, net charge density, electron and ion density, and ion velocity. In terms of magnitude, the potential increases from about 17 to 68 as the magnitude of electron impact ionization frequency increases from 0 to 0.02. The net charge density is minimum at the sheath edge, and it increases towards the wall with its maximum peak value obtained in the sheath region. Once the maximum occurs, the net charge density decreases towards the wall. For the same increment of electron impact ionization frequency, the particle density decreases towards the wall, however, the decreasing rate is much slower for the ions than that of electrons. The electron density almost diminished at the wall while few ion densities reach the wall. Moreover, the velocity of ions increases toward the wall and the magnitude velocity with which it strikes the wall increases from about 5.7 to 11.6. References: [1] T. E. Sheridan and J. A. Goree, IEEE Trans. Plasma Sci. 17, 884 (1989). [2] K. U. Riemann, J. Phys. D: Appl. Phys. 24(4), 493 (1991). [3] N. Sternberg, V. Godyak, and D. Hoffman, Phys. Plasmas 13, 063511 (2006). [4] S. Basnet, A. Maskey, A. Deuja, and R. Khanal, Phys. Plasmas 28, 083705 (2021).

Date/Time:
ET:      2023-07-15 04:30:00
Nepal: 2023-07-15 14:15:00

Abstract Number: ANPA2023-N0009

Presenting Author: Prakash Man Shrestha

Presenter's Affiliation: Patan Multiple Campus, IoST, TU, Nepal

Title: Temporal variation of Atmospheric Ozone over Kathmandu Valley

Location: Central Department of Physics, T.U., Nepal

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The main aim of this project is to study temporal the variation of atmospheric ozone over Kathmandu Valley (27.72o N, 85.32oE, 1350 m asl). The daily data of Total Ozone column (TOC) is received from OMI satellite of NASA for 11 years of solar cycle-24 (2008 to 2018). The monthly, seasonal and annual variations of TOC are studied. The maximum value of monthly average of TOC is found 282 ± 8 DU in April, while the minimum value is found 252 ± 7 DU in December. The results also shows that TOC is seasonal dependent with larger value of TOC 174 ± 10 DU in pre monsoon and lower value of 258 ± 5DU in post monsoon. The annual average of TOC exhibits slightly variable with a maximum 280 ± 15 DU in 2015 and minimum 249 ± 10 DU in 2009. The average value of TOC during the whole study period is found 267 ± 17 DU, which indicates a good amount of stratospheric ozone content over Kathmandu Valley. Continuous wavelet transform (CWT) is also used to analysis variation of TOC. The power density of TOC 25000 DU2 is recorded from 2010 to mid of 2011 and 2015 to end of 2017. This research work is beneficial for the further identification and analysis of TOC at different places with same geography.

Date/Time:
ET:      2023-07-15 04:45:00
Nepal: 2023-07-15 14:30:00

Abstract Number: ANPA2023-N00010

Presenting Author: Puranjan Kafle

Presenter's Affiliation: Western Regional Campus,Pokhara

Title: Loop Quantum Gravity: A interdisciplinary topic

Location: Central Department of Physics, T.U., Nepal

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Abstract Loop quantum gravity (LQG) is a theoretical framework that attempts to reconcile the principles of general relativity, the theory of gravitation, with quantum mechanics, the theory that describes the behavior of matter and energy at the smallest scales. In LQG, space-time is quantized into discrete units, and the geometry of space-time is described in terms of spin networks, which are graphs representing the interconnections between space-time points. There are various aspects or fundamentals to this topic. This report aims to provide a wide view on various aspects of their fundamentality and provide with a wider perspective to its challenges and sucess majors to upbring as a major contendor for the holy grail of physics "The Theory of Everything ". This report is included with details on tge basic principles of Loop Quantam Gravity. It includes : Canonical quantization,Discrete space-time,Holonomies and connections,Spin networks,Background independence,Diffeomorphism invariance,Emergence of space-time. Also providing a wider view to its challenges and promising future directions, This report impacts on other various big topics in physics such as Cosmology, Particle Physics, Philosophical bibilographies as well as Quantam Mechanics.

Date/Time:
ET:      2023-07-15 05:00:00
Nepal: 2023-07-15 14:45:00

Abstract Number: ANPA2023-N0008

Presenting Author: Purna Jyoti Shakya

Presenter's Affiliation: Patan Multiple Campus, IoST, Tribhuvan University, Nepal

Title: Magnetospheric Pc Pulsation as seen from Solar Wind and Geomagnetic Indices during the September 8th 2017 Solar Storm

Location: Central Department of Physics, T.U., Nepal

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Ultra low frequency (ULF) waves are an important consideration to identify the dominant process that transfer energy from solar wind to Earth’s inner magnetosphere as they propagate electromagnetic energy over vast distance with little dissipation. The waves observed on the Earth depends on conditions in the solar wind and in the magnetosphere. In this work, we investigate the Pc pulsation observed in the 12-15 UT time interval during geomagnetic storm of September 8th 2017 using data from the SuperMAG and the OMNIWeb services. We used Pc pulsation data observed at T48 station (geographic latitude: 54.8o, geographic longitude: 293.19o), Schefferville, Canada. Cross-correlation analysis shows that Pc2, Pc3, Pc4 and Pc5 ULF wave are positively correlated with interplanetary magnetic field, AE index and Polar cap index. Similarly, cross-correlation of Pc pulsations with solar wind density (Nsw), solar wind pressure (Psw) and solar wind velocity (Vsw), shows that they are positively correlated with no time lag, indicating sudden increase in solar wind density and velocity due to IP shocks result in a gradual increase in dynamic solar wind pressure and sudden compression from the Earth’s dayside magnetosphere. As a result, acoustic magnetic wave are ejected into the magnetosphere. Key words: Ultra Low Frequency (ULF), Pc Pulsation, Geomagnetic Storm, Magnetosphere.

Date/Time:
ET:      2023-07-15 05:15:00
Nepal: 2023-07-15 15:00:00

Abstract Number: ANPA2023-N0002

Presenting Author: Keshab Pandey

Presenter's Affiliation: Department of Physics, Daegu University, Gyeongsan 38453, South Korea

Title: Modification of Tungsten Disulfide for Electrochemical Energy Storage and Conversion

Location: Central Department of Physics, T.U., Nepal

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Tungsten disulfide (WS2) is modified, by using ambient solution plasma, for electrochemical energy applications which are hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and flexible supercapacitor applications. Herein, the effect of time-dependent plasma treatment on WS2 is investigated, resulting that the optimum time (60 min) shows the best performances of low overpotential of -0.19 V at -10 mA cm-2 and 0.21 V at 10 mA cm-2 with the corresponding Tafel slopes of 113 mV dec-1 and 124 mV dec-1 for HER and OER, respectively. In addition, a high specific capacitance of 157.5 F g-1 at 1 A g-1 with an energy density of 14 Wh kg-1 and power density of 400 W kg-1 for the flexible supercapacitor is obtained. Reliable flexibility with high specific capacitance retention (94.0%) and coulombic efficiency (89.5%) after 5,000 cycles are also demonstrated. The increased electrochemically active surface area, lower impedance, and the phase transition from 2H to 1T, compared to the precursor WS2, are ascribed to the better HER, OER, and supercapacitor performance. Keywords: Tungsten disulfide; ambient solution plasma; hydrogen evolution reaction; oxygen evolution reaction; supercapacitor.

Date/Time:
ET:      2023-07-15 05:30:00
Nepal: 2023-07-15 15:15:00

Abstract Number: ANPA2023-N00081

Presenting Author: Rajendra Neupane

Presenter's Affiliation: Central Department of Physics

Title: Identification of a Soft X-ray Flaring Range in OJ 287 from April 2020 Observation through Temporal, Spectral, and SED Modeling Analysis

Location: Central Department of Physics, T.U., Nepal

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We performed a temporal and spectral study of emission from blazar OJ 287 using an XMM-Newton observation in April 2020. Among the various fitted models used to characterize the spectrum, (log-parabola+black-body) model fits the spectrum best which indicates that the observed X-ray emission is a result of a combination of synchrotron and thermal emission processes, implying that the overall X-ray emission is driven by both non-thermal and thermal mechanisms. The value of fractional variability of 2.073±0.037 indicates that the source is highly variable. The results of our analysis show a significantly higher net count rate of 5.651±0.025. Despite the much shorter exposure time of just 9 ks in April 2020, compared to the 53 ks and 19 ks exposure time for the 2015 and 2018 observations respectively, the effect of the flare is still apparent in the higher net count rate (5.651±0.025) obtained from the more recent observations in April 2020.

Date/Time:
ET:      2023-07-15 06:00:00
Nepal: 2023-07-15 15:45:00

Abstract Number: ANPA2023-N00019

Presenting Author: Ramesh Khanal and Rajan Ghimire

Presenter's Affiliation: Student

Title: Tungsten and Molybdenum Surfaces Exposed to Warm Deuterium Ion Plasma with q-NoneTungsten and Molybdenum Surfaces Exposed to Warm Deuterium Ion Plasma with q-Nonextensive Distribution of Electron Tungsten and Molybdenum Surfaces Exposed to Warm Deuterium Ion Plasma with q-Nonextensive Distribution of Electrons

Location: Central Department of Physics, T.U., Nepal

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This work is concerned with the effect of non-Maxwellian electrons and obliqueness of magnetic field on magnetized plasma sheath characteristics, in which plasma interacts with tungsten (W) and molybdenum (Mo) surfaces via non-neutral plasma sheath using two fluids model. It is assumed that the singly charged positive ions are treated as warm fluid whereas the electrons obey q-nonextensive distribution. It is found that the q-nonextensive distributed electrons and the temperature of ions affect the entrance velocity of positive ions, which is a key parameter in the plasma sheath formation. Also, the nonextensive parameter q affects the distribution of ions and electrons in the sheath region and their distributions explicitly related with the electrostatic potential variation. The parallel and perpendicular components of ions velocity are affected by the obliqueness of magnetic field. As the nonextensivity of electrons increases, the gradient in electric potential increases towards the wall and hence the impact energy also increases. The obliqueness of magnetic field and impact energy of ions is a key factor that determines the physical sputtering rate, particle reflection and absorption from the target surface. Furthermore, the probability of particle reflection coefficient from the W-surface is higher than that of Mo-surface.

Date/Time:
ET:      2023-07-15 06:15:00
Nepal: 2023-07-15 16:00:00

Abstract Number: ANPA2023-N00016

Presenting Author: Roshan Chalise

Presenter's Affiliation: Central department of Physics, Tribhuvan University, Kathmandu, Nepal,

Title: CHARACTERIZATION AND APPLICATION OF ATMOSPHERIC PRESSURE PLASMA FOR ENHANCED SEED GERMINATION AND AGRICULTURAL GROWTH

Location: Central Department of Physics, T.U., Nepal

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Atmospheric pressure plasma (APP) finds extensive applications across various fields to enhance human life quality such as food safety (microbial inactivation, bacteria-free food), healthcare (cancer treatment, wound healing, blood coagulation, dental procedures), micro-fabrication (etching, chemical vapor deposition), agriculture (insecticide, sterilization, growth enhancement, fertilizers), and environmental science (air and water pollution treatment). In this study, we have developed and characterized gliding arc, dielectric barrier discharge, and plasma jet systems using natural air in the laboratory of the Central Department of Physics. These plasma systems were then applied in agriculture fields (such as leaf mustard, paddy, cauliflower, coriander seed, and mushroom) both directly and indirectly (by exposing plasma to water and subsequently using the treated water on crops). The APP generates various reactive species, including nitrate, nitrite, hydrogen peroxide, and OH functional groups, which alter the properties of the seeds, seed germination, seedling growth, and water. The treated substrates exhibit decreased contact angles, rendering seeds more hydrophilic, enabling increased water absorption and improved germination rates. Plasma-activated water contains a higher concentration of reactive species, promoting growth enhancement and serving as a fertilizer and pesticide.

Date/Time:
ET:      2023-07-15 06:30:00
Nepal: 2023-07-15 16:15:00

Abstract Number: ANPA2023-N00030

Presenting Author: Roshan Pudasaini

Presenter's Affiliation: Kathmandu University

Title: Muonium behavior in derivatives of Hemoglobin: a DFT study

Location: Central Department of Physics, T.U., Nepal

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Muon is a spin-halved subatomic particle that can be found in cosmic rays (naturally) and accelerator facilities through pion decay. It has a mass that is around 207 times that of an electron and 1/9 that of a proton. Since the muon's gyromagnetic ratio is around three times greater than that of the proton, it is higher sensitive with respect to proton to magnetic field. Muon has two unique properties that make them unique tools: spin polarization and asymmetric decay to positron (caused by parity violation in weak contact). By stopping muons into the injected material, the local electronic and spin states of materials can be revealed through the muon spin rotation and relaxation (muSR) approach. Muonium on the other hand, is bound state of two lepton particles - positive muon and an electron with similar chemical properties of H atom. Muon method examines the local and dynamic state of spin, electron, proton, ions, and hydrogen in materials. It can also investigates phenomena based on these processes, such as electron transfer in the respiratory system, photosynthesis process, illness detection, clinical and medical fields, and reaction dynamics, catalytic processes, molecule concentration, magnetic behaviors etc. In this study, the stopping site and charge states of muon and muonium in derivatives of hemoglobin have been studied through the first-principles approach. The stopping site of muon and muonium in derivatives of hemoglobin with extended main chain structure have been estimated. The HOMO-LUMO gap and hyperfine coupling constant will be extracted from external files to understand the electronic states and interaction of muon with nearby nucleus. By analyzing the stopping sites of muon and muonium within the hemoglobin structures, we aim to understand their preferential binding locations and the influence of molecular variations on their behavior. The obtained results shed light on the interactions between muon, muonium and the hemoglobin derivatives, revealing potential implications for their reactivity and functionality. Our DFT calculations not only contribute to the fundamental understanding of muon and muonium behavior in hemoglobin but also pave the way for further exploration of their interactions with other biomolecules. The findings from this study can potentially guide future experimental investigations and inspire the development of novel applications of muon in cancer research. In the initial findings of the muonium behavior within the heme group of Deoxyhb, Oxyhb, and Cohb, we observed that the muonium tends to settle near the nitrogen atom of the pyrrole ring in the heme group. Conducting a theoretical analysis will be crucial in determining the precise location where the muon stops and the specific charge states it adopts in hemoglobin. This information will be invaluable in supporting the experimental investigation.

Date/Time:
ET:      2023-07-15 06:45:00
Nepal: 2023-07-15 16:30:00

Abstract Number: ANPA2023-N00082

Presenting Author: Saroj Pandeya

Presenter's Affiliation: Central Department of Physics, Tribhuvan University, Kirtipur, Kathmandu 44613, Nepal

Title: Dust charge fluctuation and ion acoustic wave propagation in dusty plasma with q-nonextensive hot and Maxwellian cold electrons

Location: Central Department of Physics, T.U., Nepal

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We have employed the self-consistent kinetic theory to study the linear dispersion relation of_x000D_ ion acoustic waves in four-component plasma consisting of nonextensive hot electrons,_x000D_ Maxwellian cold electrons, positive ions, and dust particles. The dust charging process with_x000D_ the modified ion acoustic wave damping, as well as its unstable mode, has been graphically_x000D_ illustrated. It is found that the dust charging mechanism depends on the density of hot_x000D_ electrons, the degree of nonextensive electron distribution, and the temperature ratio of hot_x000D_ to cold electrons. It is shown that the damping and instability rates of ion acoustic waves due_x000D_ to dust charge fluctuations explicitly depend on the choice of electron distribution and the_x000D_ magnitude of dusty plasma parameters. In addition, we have studied the ion acoustic Landau_x000D_ damping in the absence of dust particles. It is found that the weak damping region broadens,_x000D_ while the strong damping region shrinks and is shifted toward the short wavelength region_x000D_ for the increase in the temperature ratio of hot to cold electrons.

Date/Time:
ET:      2023-07-15 07:00:00
Nepal: 2023-07-15 16:45:00

Abstract Number: ANPA2023-N0001

Presenting Author: Sujan Bhandari

Presenter's Affiliation: Central Department of Physics

Title: Comparative study of preparation and characterization of phosphoric acid activated carbon from different precursors for energy storage applications

Location: Central Department of Physics, T.U., Nepal

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Phosporic Acid (H_3PO_4) can be used to activate different precursors and produce activated carbon(AC) ,a porous material with high adsorption capacity and surface area. This research compares how AC is made using different locally available precursors namely Amla seeds and Harro seeds. We look at how carbonization temperature affects the AC yield, surface area, pore structure and electrochemical properties. We use different methods to analyze the AC samples such as scanning electron microscopy, Fourier transform infrared spectroscopy and cyclic voltammetry. We show that the best conditions for making AC depends on the type of precursor. We also talk about the use of AC for storing energy.

Date/Time:
ET:      2023-07-15 07:15:00
Nepal: 2023-07-15 17:00:00

Abstract Number: ANPA2023-N00021

Presenting Author: Suresh Basnet

Presenter's Affiliation: Tribhuvan University

Title: Ion flow and dust charging at the sheath boundary for dusty plasma with electron emitting surface: Applications to laboratory and lunar dusty plasmas

Location: Central Department of Physics, T.U., Nepal

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In laboratory and space plasmas, the emission of electrons from the surface significantly affects the characteristics of plasma sheath formed at that surface, which is crucial to understanding the overall plasma-wall interaction mechanism. In this work, the collisional fluid model is used for laboratory dusty plasma, whereas collisionless model is used for lunar dusty plasma. We have extended the Bohm sheath criterion for the formation of stable plasma sheath in account of electron emission from the surface, loss of ion flux, and gas pressure for the collisional laboratory dusty plasmas. It is found that ion flow at the sheath boundary is considerably influenced by the concentration of electron emission, ion loss term, and gas pressure. The equilibrium evolution of dust charge explicitly determines the magnitude of ion flow at the sheath boundary. The plasma parameters adopted in the present case are reliable in laboratory and space dusty plasmas, especially dusty plasma environment on the lunar surface. The surface of Moon and dust grains are electrically charged due to interaction of solar-wind plasma and photoemission electrons from the surface due to solar ultra-violet radiation. In addition, the plasma sheath characteristics, dust charging process, and stable dust levitation on the sheath region have been studied.

Florida International University, Miami, Florida, USA

Please look below for detailed schedule.


Date/Time:
ET:      2023-07-15 10:00:00
Nepal: 2023-07-15 19:45:00

Abstract Number: ANPA2023-N00092

Presenting Author: Vivek N. Prakash (Invited)

Presenter's Affiliation: Department of Physics, University of Miami, Miami, FL

Title: Fascinating Biophysics in Simple Marine Animals

Location: Florida International University, FL, USA

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Animals are characterized by their movement, and their tissues are continuously subjected to dynamic force loading. Tissue mechanics determines the ecological niches that can be endured by a living organism. In the first part of my talk, I will present our surprising discovery of motility-induced tissue fractures and healing in a simple, early divergent marine animal – the Trichoplax adhaerens. I will demonstrate how fracture mechanics governs dramatic shape changes and asexual reproduction in this animal. In the second part of my talk, I will focus on the role of fluid mechanics in marine invertebrates. In starfish larvae, we discovered that ciliary arrays give rise to a beautiful pattern of slowly evolving vortices which determine a physical tradeoff between feeding and swimming.

Date/Time:
ET:      2023-07-15 11:00:00
Nepal: 2023-07-15 20:45:00

Abstract Number: ANPA2023-N00049

Presenting Author: Abin shakya

Presenter's Affiliation: School of Electrical Engineering and Computer Science, Louisiana State University, Baton Rouge, LA 70803, USA

Title: First-principles molecular dynamics simulation and analysis of bulk Earth melt system: Insights into metal-silicate differentiation

Location: Florida International University, FL, USA

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To gain insights into the chemical evolution of Earth during its accretion phase, we use first-principles molecular dynamics to simulate a mixed metallic liquid-silicate magma ocean system. Our simulation considers a composition resembling that of the bulk Earth, comprising of four major elements: Fe, Mg, Si, and O in the amounts of 35.7, 19.0, 15.2, and 30.2 wt.%, respectively. We simulate the supercell containing Fe85Mg104Si72O251 under high pressure-temperature conditions (30-40 GPa and 3000-4000 K). By performing coordination/bonding and space-decomposition analyses along with interactive visualization of the atomic position-time series, we predict a chemical phase separation within the simulated melt system. This separation leads to the formation of an iron-rich region, corresponding to the metallic core, and an iron-poor region, corresponding to the silicate mantle. The estimated composition of the iron-rich phase consists of 89.0, 1.1, 4.8, and 5.1 wt.% of Fe, Mg, Si, and O, respectively. Conversely, the corresponding elemental proportions in the magma ocean phase are approximately 8.7, 29.2, 19.8, and 42.3 wt.%, resembling a pyrolytic mantle. Furthermore, we conduct simulations and analyses to examine the incorporation of two important volatile elements, H and N, within the metal-magma ocean system. Our preliminary analysis suggests that both elements exhibit a preference for partitioning into the liquid metal compared to the silicate magma ocean.

Date/Time:
ET:      2023-07-15 11:15:00
Nepal: 2023-07-15 21:00:00

Abstract Number: ANPA2023-N00050

Presenting Author: Amar B Karki

Presenter's Affiliation: Scientific Instruments Inc.

Title: SI Temperature Probes for Cryogenic field

Location: Florida International University, FL, USA

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SI Temperature Probes for Cryogenic field Amar B Karki Scientific Instruments Inc Email: akarki@scientificinstruments.com Abstract Measurement of Physical properties such as temperature, pressure, density is key to the Industries, Medical facilities, Space Shuttles and Research Institutions. Since 1967, Scientific Instruments (SI) has been a leader in the production of instruments such as Temperature probes and Density meters. SI is committed to our goals and vision to be the worldwide leader in cryogenic measurement technology through continued innovation and advancements in technology. In this presentation, I will discuss on the SI products and selection of a suitable sensor based on application, temperature range, sensitivity, response time, stability, and packaging. Ruthenium Oxide Temperature Sensors are thick film resistors which adhere to are available with calibration down to 20mK or grouped/interchangeable. The ruthenium oxide temperature sensor offers excellent performance characteristics in magnetic field environments. The SI Silicon Diode Temperature Sensors operate over a wide temperature range (1.5K to 500K) and are miniature in size. They are linear over a wide temperature range interval, have high sensitivity in their lower range, and are interchangeable to a standard V/T curve. We recently introduced Zirnox sensor which is made of a thin film of zirconium oxynitride. This is a resistive temperature sensor that can operate over a wide temperature range (20 mK to 420K), exhibits negligible calibration shifts when exposed to magnetic field and ionizing radiation environments. SI offers a variety of temperature probes that allow mounting in hazardous environments. These units are constructed of stainless steel, hermetically sealed, and the sensing element is mounted in a thermal epoxy at the tip. The probes are designed for direct immersion or thermowell applications. The SI-7000 LTD is the most dependable solution for level, temperature, and density profiling in LNG & LPG Storage Tanks.

Date/Time:
ET:      2023-07-15 11:30:00
Nepal: 2023-07-15 21:15:00

Abstract Number: ANPA2023-N00048

Presenting Author: Bashu Dev Khanal

Presenter's Affiliation: Old Dominion University

Title: "Investigation of trapped vortex induced hot-spot in single cell niobium superconducting radio frequency cavity"

Location: Florida International University, FL, USA

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A significant source of residual losses in superconducting radiofrequency cavities is the magnetic field trapped during the cooldown due to the incomplete Meissner effect. In this contribution, we present the results of combined magnetic and temperature mapping measurements at 2 K on a single cell niobium cavity resonating at 3.0 GHz. A local magnetic field was produced at different locations near the cavity surface during cooldown, resulting in hot-spots and allowing estimating the contribution to radiofrequency losses due to trapped vortices.

Date/Time:
ET:      2023-07-15 11:45:00
Nepal: 2023-07-15 21:30:00

Abstract Number: ANPA2023-N00023

Presenting Author: Bhanu Ghimire

Presenter's Affiliation: University of North Carolina at Charlotte

Title: Design and Fabrication of Dipole Coupled Microbolometer as Infrared Sensor

Location: Florida International University, FL, USA

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Dipole coupled microbolometer uses planar lithographic antennas to couple infrared radiation into the feed line. In this research, irradiance values at the dipole arm have been studies for direct incidence and using reflector behind substrate. Bolometer has been fabricated by sputtering process to measure electrical property and detectivity of infrared antenna. A new method to calculate the radiation efficiency based on the spatial and angular response of infrared antennas is presented and used to evaluate their performance. We have observed Fresnel losses in the system of around 12% due to reflection, absorption and transmission and concentration ratio ranges from 60 to 85 at the feed point. A dipole radiation pattern was studied for fixed length of 7.5 micrometer for operating wavelength 28.3 THz. The observed radiation pattern shows main lobe and side bands indicating capability of antenna for multiple communication.

Date/Time:
ET:      2023-07-15 12:00:00
Nepal: 2023-07-15 21:45:00

Abstract Number: ANPA2023-N0004

Presenting Author: Bibandhan Poudyal

Presenter's Affiliation: University of Rochester

Title: Measuring the Directness of Accessibility to City’s Amenity using Network First Passage Distances

Location: Florida International University, FL, USA

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Accessibility in general is an abstract concept to quantify. However, several researchers have attempted to quantify accessibility to amenities (city structures) either using spatial heterogeneity—diversity and density of amenities in space or looking for topological (street) connectivity of those amenities. Only few have used the correlation between spatial diversity and topological connectivity of urban amenities to understand the accessibility. We develop a simple, principled, and flexible framework to characterize the directness of accessibility among heterogeneous amenities in a city, which we call the Class First Passage Difference (CFPD). The CFPD quantifies the excess travel distance incurred when using the street network to route between different pairs of amenity types, summarizing both the spatial and topological correlations among amenities in a city. Our measure showed significant correlation with different prosperity and accessibility indicators when compared with the null model—random distribution of amenities keeping their frequency constant. Our measure provides a principled, interpretable and complementary perspective to existing measures of urban accessibility.

Date/Time:
ET:      2023-07-15 12:15:00
Nepal: 2023-07-15 22:00:00

Abstract Number: ANPA2023-N00022

Presenting Author: Dipendra Khatri

Presenter's Affiliation: University of Central Florida

Title: Spatiotemporal characterization of few-cycle Bessel- Gaussian and vector waveforms in the mid-infrared

Location: Florida International University, FL, USA

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Spatiotemporal characterization of few-cycle Bessel-Gaussian and vector waveforms in the mid-infrared Dipendra Khatri1, Yangyang Liu1, Shima Gholam-Mirzaei2, Tran-Chau Truong1, Andre Staudte2, Paul B Corkum2 and Michael Chini1,3 1Department of Physics, University of Central Florida, Orlando FL 32816 2Joint Attosecond Science Laboratory (JASLab), National Research Council of Canada and University of Ottawa, Ottawa, Ontario K1A 0R6, Canada 3CREOL, the College of Optics and Photonics, University of Central Florida, Orlando FL 32816 Author e-mail address: dskhatri@knights.ucf.edu Abstract: Knowledge of the space-time properties of ultrafast laser pulses is necessary both for characterizing spatiotemporal distortions and for applications using structured beams. In the past, such space-time characterization has been achieved using either measurements of linear interference between an ‘unknown’ pulse and a well-characterized ‘reference’ pulse in the near-infrared and visible or using electro-optic sampling (EOS) in the THz spectral region. Very recently, EOS-based imaging techniques have been extended to the near-infrared, but this requires the synchronization of the unknown pulse with a few-femtosecond sampling pulse to achieve the necessary time resolution. Here, we demonstrate that a novel variant of TIPTOE (tunnel ionization with a perturbation for the time-domain observation of electric fields) capable of resolving three-dimensional (2D space + time) laser waveforms. By using multiphoton nonlinear excitation in a silicon-based CMOS image sensor as a sub-cycle “temporal gate”, we do the measurement of the full space, time, and polarization state of structured (Vector, and Bessel-Gaussian beams) few-cycle mid-infrared laser waveforms. The reversal of the electric field direction in adjacent Bessel rings, and radially polarized polarization-state of the vector beam is directly observed in the field-resolved measurement. The experiment is carried out using few-cycle mid-IR pulses centered near 3.4 μm, which are generated by nonlinear compression of multi-cycle pulses from an optical parametric amplifier (OPA).

Date/Time:
ET:      2023-07-15 13:30:00
Nepal: 2023-07-15 23:15:00

Abstract Number: ANPA2023-N00033

Presenting Author: Hugo Perez

Presenter's Affiliation: Florida International University

Title: Multimeric Assembly and Membrane Pore Forming Dynamics of the Lantibiotic Peptide Nisin

Location: Florida International University, FL, USA

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Multidrug resistance in bacteria has led to a dire need for the development of new antibiotics with novel modes of action which can evade existing bacterial defenses. By targeting Lipid-II, antibiotic peptides such as Nisin disrupt bacteria’s ability to synthesize their cell wall. Lantibiotics bind to Lipid-II’s pyrophosphate moiety rather than the more commonly targeted peptide moiety. This means that bacteria that develop resistance to commercial antibiotics should still be vulnerable to lantibiotics. In this study, we use atomic-scale molecular dynamics computational studies to model stable oligomeric pore structures of nisin and investigate their dynamics and stability. We test a variety of conformations of nisin pore structures and motifs to find a viable structure. We also explore the role that Lipid-II plays in the formation and in maintaining the stability of the pores as well as the role transmembrane potentials play in the nature of the pores, including the channel volume and the ability of Nisin pores to exhibit ion selectivity.

Date/Time:
ET:      2023-07-15 13:45:00
Nepal: 2023-07-15 23:30:00

Abstract Number: ANPA2023-N00011

Presenting Author: Jose L. Parra

Presenter's Affiliation: Florida International University

Title: The Gravitational Energy according to the General Theory of Relativity

Location: Florida International University, FL, USA

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The actual opinion is that we are living in a universe almost full of darkness. To bring some light into play, it will be introduced here an exact solution of Einstein’s equations of General Relativity with consequences in agreement with the known galactic data. Also, the model allows us to forecast that a clear gravitational perturbation was going to come from the center of the Milky Way at a specific date and time. That event was observed as expected with two modified Cavendish’s balances within 2.6 kilometers of separation.

Date/Time:
ET:      2023-07-15 14:00:00
Nepal: 2023-07-15 23:45:00

Abstract Number: ANPA2023-N00083

Presenting Author: Joseph Maerovitz

Presenter's Affiliation: Florida International University

Title: Recent Developments in the Non- Perturbative Structure of the Pion

Location: Florida International University, FL, USA

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Several works have attempted to understand the pion valence partonic distribution function (PDF), both experimentally and theoretically. Questions remain, especially for the high x region. Using the recently developed Residual Field Model, we calculate the pion valence PDF in the range of 0.1

Date/Time:
ET:      2023-07-15 14:15:00
Nepal: 2023-07-16 00:00:00

Abstract Number: ANPA2023-N00037

Presenting Author: Kyle J Cahill

Presenter's Affiliation: Georgia State University

Title: Connectivity in the Left Dorsal Stream is Enchanced in Video Gamers

Location: Florida International University, FL, USA

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Video games provide sensory-rich, vision-dominated, competitive environments, in which players are continually challenged for moment-to-moment spatial navigation and decision-making. Recent studies have shown that video game players (gamers) enjoy the cognitive benefit of an increased reaction time, compared to non-gamers in making vision-based sensorimotor decisions. Hypotheses for how the brain processes visual information include the ‘two-streams’ model in which the visual pathway is bifurcated into dorsal and ventral streams. However, it is still unknown if video game playing can influence structural and functional changes in the visual streams of the brain. Here in this study, we examined the structural connectivity of the dorsal and ventral streams in gamers compared with non-gamers. After utilizing a Wilcoxson test on the metrics obtained from diffusion spectral imaging (DSI) analysis, we found that white matter tracts in the left dorsal stream between the left superior occipital gyrus and the left inferior parietal lobule were enhanced in video gamers indicated by elevated fractional anisotropy (FA) and normalized quantitative anisotropy (NQA) measures. The functional connectivity between the left superior occipital gyrus and the left superior parietal lobule was enhanced in video game players. Together the enhanced structural and functional connectivity within the left occipital-parietal regions in the visual stream may provide insight into the structural and functional basis for the beneficial effects of video game playing experience and may help explain the improved behavioral performance of video gamers in vision-based sensorimotor decision-making tasks.

Date/Time:
ET:      2023-07-15 14:30:00
Nepal: 2023-07-16 00:15:00

Abstract Number: ANPA2023-N00034

Presenting Author: Michael D. Cioffi

Presenter's Affiliation: Florida International University

Title: Role of Lipid Composition on Ebola Virus Matrix Protein VP40 Interactions with the Human Plasma Membrane

Location: Florida International University, FL, USA

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The Ebola virus is a highly dangerous virus which can cause severe hemorrhagic fever in humans leading to high fatality rates. The Ebola virus matrix protein VP40 is the major protein responsible for the formation of the viral matrix by localizing and assembling it at the inner leaflet of the human plasma membrane (PM). This assembly leads to the formation of virus-like-particles (VLP) and eventual budding. Anionic lipids PI(4,5)P2 (PIP2) and Phosphatidylserine (PS) have been shown to facilitate VP40-PM binding through electrostatic interactions with cationic VP40 residues. It has been determined that Phosphatidic Acid (PA), resulting from the enzyme Phospholipase-D (PLD), may also play an active role in this process. We performed coarse-grained molecular dynamics (CGMD) simulations to investigate the effects various lipids have on VP40-lipid interactions. We used a triple-dimer structure of VP40 and a PM composed of various lipid types. Contact analyses show interactions with specific cationic VP40 residues that facilitate most of the lipid interactions. Interaction strengths between VP40 residues and lipid headgroups are found to vary when PA was included in the PM compared to when it was not. Radial distribution functions also show differences in local lipid clustering when PA was introduced into the PM. These simulations provide new insights on multi-dimer VP40 interactions with the human PM and how different lipid compositions may influence overall membrane association.

Date/Time:
ET:      2023-07-15 14:45:00
Nepal: 2023-07-16 00:30:00

Abstract Number: ANPA2023-N00047

Presenting Author: Nishchal Thapa Magar

Presenter's Affiliation: George Mason University

Title: Atomistic simulation of dislocation nucleation in defect-free copper nanoparticles

Location: Florida International University, FL, USA

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It is well-known that materials become increasingly stronger as their dimensions are reduced to the sub-micrometer scale and even stronger on the nanometer scale. While the “smaller is stronger” paradigm is widely accepted, the exact mechanisms behind the high strength of nanometer-scale objects remain elusive and call for further investigations. In particular, defect-free metallic nanoparticles often demonstrate compressive strength approaching the theoretical strength of the material. The underlying plasticity mechanism in such particles is believed to be related to the nucleation of lattice dislocations on the particle surface. In this work, we applied large-scale molecular dynamics simulations to better understand the onset of plastic deformation in Cu nanoparticles. Single-crystalline nanoparticles with diameters ranging from 17 to 90 nm had smoothed Wulff shapes and were deformed by simulated compression normal to the (111) facets. The particle strength increased with decreasing diameter, reaching about 26 GPa for the smallest size tested. The plastic deformation was initiated by the nucleation of a single dislocation or a group of dislocations on either the top or bottom facet of the particle, usually near a facet corner. Two nucleation mechanisms were identified. In the first mechanism, a Shockley partial half-loop nucleated at the surface after multiple nucleation attempts. After the nucleation of a trailing partial, the full dislocation rapidly traversed the nanoparticle resulting in the nucleation of multiple additional dislocations and a stress drop. In the second mechanism, a partial dislocation loop nucleated under the surface homogeneously and grew on a (111) plane near parallel to a top or bottom facet. The loop eventually reached the particle surface and caused an avalanche of new dislocations and a stress drop. This work has clarified the atomic-scale mechanisms of dislocation-controlled plasticity in nanoscale materials.

Date/Time:
ET:      2023-07-15 15:00:00
Nepal: 2023-07-16 00:45:00

Abstract Number: ANPA2023-N00051

Presenting Author: Puskar Chapagain

Presenter's Affiliation: Southern Arkansas University

Title: Unlocking the Potential: Harnessing Metallic Particle Doping to Fine-Tune the Bandgap of TiO2

Location: Florida International University, FL, USA

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Titanium dioxide (TiO2) holds immense potential as a semiconductor material for a variety of applications such as solar cells, photocatalysis, sensors, and electronics. The increasing interest in TiO2 lies in its optoelectronic properties, which could be heavily influenced by its bandgap. As such, the ability to fine-tune the bandgap of TiO2 is of utmost importance to enhance its properties for specific uses. One of the most widely employed methods involves doping TiO2 with metal particles, resulting in a modification of its inherent bandgap. Consequently, leads to improved performance and expands the range of potential applications. Within this project, we intend to investigate the manipulation of TiO2's bandgap, utilizing UV-Vis spectroscopy, and explore the intricate relationship between different doped elements and the resulting band structure.

Date/Time:
ET:      2023-07-15 15:30:00
Nepal: 2023-07-16 01:15:00

Abstract Number: ANPA2023-N00035

Presenting Author: Santosh Khatri

Presenter's Affiliation: Florida International University

Title: Nanoconfined based Single-Entity Analysis: Unveiling Small Molecule Detection and Intermolecular Interactions in crowded environments.

Location: Florida International University, FL, USA

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The behavior of individual molecules plays a crucial role in biochemical processes, which in turn influence the properties of cells and ultimately impact human behavior. Nanopore sensing, a cutting-edge technique for detecting and studying molecules at the single-molecule level, holds immense promise in unraveling the intricate details of molecular behavior. However, the sensitivity of existing nanopore methods, such as nanopipettes, is limited by the small size and fast speed of biomolecules. To address this problem, a novel approach of nanoconfinement at the nanopipette tip has been developed. This innovative method allows for the detection of smaller biomolecules, such as DNA bases and short peptides, using a nanopipette with a pore size over 10 times larger than the size of the biomolecule. The technique involves backfilling the nanopipette with biomolecules and then driving them out using concentration gradient and/or nanopore bias. This breakthrough enables deeper insights into the intermolecular interactions of various biomolecules and enables the detection of small single molecules at a scale of nearly 1 nanometer. In summary, the ability to detect and study small biomolecules with enhanced sensitivity using nanopipettes opens an exciting opportunity for understanding the intricate world of molecular behavior and has the potential to greatly impact fields such as drug discovery, personalized medicine, and biotechnology, opening new avenues for research and application in the field of molecular sciences.

Date/Time:
ET:      2023-07-15 15:45:00
Nepal: 2023-07-16 01:30:00

Abstract Number: ANPA2023-N00075

Presenting Author: Shree Bhattarai

Presenter's Affiliation: Torqata Data and Analytics

Title: Building end-to-end machine learning pipeline to predict tire attributes using Kubeflow

Location: Florida International University, FL, USA

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When a customer visits a tire shop to purchase/replace tire, the most important factors that come into play are whether (i) the size of the tire fits their vehicle? (ii) the tire design suits the surface they drive on? (Smooth road, Rough/Muddy road etc.), and (iii) it is suitable for the season (Winter, Summer etc.). This information is not readily available for all tires. Thus, our goal here was to build a ML model that would collect information from web search to build a classification model to extract these attributes. During this presentation, we will be talking about our approach in designing a ML pipeline utilizing KubeFlow in Google Cloud Platform to predict above three tire attributes. We will further explain how KubeFlow helps making deployment of machine learning workflows on containerized applications simple, portable and scalable.

Date/Time:
ET:      2023-07-15 16:00:00
Nepal: 2023-07-16 01:45:00

Abstract Number: ANPA2023-N00036

Presenting Author: Tej Kumar Sharma

Presenter's Affiliation: Florida International University

Title: Mutation-Induced Structural Changes in the SARS-CoV-2 Spike RBD and Enhanced ACE2 Binding in XBB.1.5 and XBB.1.16

Location: Florida International University, FL, USA

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The emergence of the XBB.1.5 and XBB.1.16 subvariants of the omicron variant of SARS-CoV-2 has raised concern due to their transmissibility and potential impact on vaccine efficacy. These subvariants have been identified by the World Health Organization (WHO) as variants of concern (VOC). Here, we investigated the impact of the mutations in the structure of the receptor binding domain of the spike protein and its interactions with the host cell receptor ACE2. We found that the mutations enhance the RBD-ACE2 interactions in both subvariants. We also observed significant structural changes in the loop and motif regions of the RBD, altering well-known antibody-binding sites and potentially rendering primary RBD-specific antibodies ineffective. Our findings suggest that these structural changes contributed to the subvariants' dominance over their predecessors, allowing for more rapid spread.

Date/Time:
ET:      2023-07-15 16:15:00
Nepal: 2023-07-16 02:00:00

Abstract Number: ANPA2023-N0003

Presenting Author: Trailokya Bhattarai

Presenter's Affiliation: UNC Charlotte

Title: Cost-effective III-Nitride Quantum Wells-Based UV-C LEDs for Microbial Disinfection—Wavelength Optimization and Solar Cell Integration

Location: Florida International University, FL, USA

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Title: Cost-effective III-Nitride Quantum Wells-Based UV-C LEDs for Microbial Disinfection—Wavelength Optimization and Solar Cell Integration Trailokya Bhattarai1, M. Yasin Akhtar Raja2, and Abasifreke Ebong1 1Department of Electrical & Computer Engineering and 2Center for Optoelectronics & Optical Communication, University of North Carolina Charlotte, NC 28223 Corresponding Email: tbhattar@uncc.edu Abstract: UV-C is known to be the most effective category of UV- Light Emitting Diodes (LEDs) for deactivating microbes and viruses. This study focuses on the design and testing of a cost-effective III-Nitride quantum wells-based UV-C LEDs in the spectral range (200 nm < λ ˂ 300 nm) for microbial disinfection. Our research objective is to determine the most effective UV-LED wavelength, dose, and exposure time for deactivating a variety of microorganisms and to develop a cutting-edge UV LED disinfection system powered by solar energy. Four prototypes of UV-C LEDs sub-systems with wavelengths range of 255 nm, 265 nm, 275 nm, and 285 nm are designed and are under rigorous testing for effectiveness. This study explores the effects of UV-C exposure on the DNA/RNA of the pathogens before and after exposure to the UV dose. The qPCR/Cell culture methods are applied for quantitative as well as qualitative analysis of the effectiveness of UV irradiation on the deactivation of microbes. Preliminary results for bacteriophages, Phi6 and MS2 are presented, and further testing on other microbes is underway. The results of this research could provide valuable insights for the development of sustainable, efficient, and cost-effective solutions to fight against the spread of infectious diseases. By developing cost-effective and efficient solar-powered UV-C LED systems, the study offers a potential solution for deactivating pathogens in a sustainable and energy-efficient manner. Preliminary results and findings will be presented with the scope of future work. Keywords: Quantum Wells, UV-C LEDs, microbial disinfection, Cell Culture/qPCR, UV dose, solar-powered UV LED

Date/Time:
ET:      2023-07-15 16:30:00
Nepal: 2023-07-16 02:15:00

Abstract Number: ANPA2023-N00032

Presenting Author: Yasir Mamun

Presenter's Affiliation: Department of Chemistry and Biochemistry, Florida International University

Title: Mechanistic insights into nucleic acid interaction of hTOP3B using molecular dynamics simulations

Location: Florida International University, FL, USA

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Human topoisomerase III beta (hTOP3B) is the only type IA topoisomerase in humans that works on both DNA and RNA substrates. This enzyme plays a crucial role in neurological development in mammals. Recently it has been found that hTOP3B is important for positive-sense single-stranded RNA viruses to replicate efficiently, making it a potential antiviral drug target. Although type IA topoisomerases of different organisms have been studied over the years, the step-by-step interaction of hTOP3B and nucleic acid substrates is still not elucidated. Molecular dynamics (MD) simulation is a tool for studying protein-substrate interaction, and we utilized this method to study the interactions between hTOP3B and nucleic acids. For this, we generated multiple models of hTOP3B complexed with DNA and RNA sequences using the hTOP3B crystal structure (PDB: 5GVC) and 8-mer single-stranded DNA and RNA sequences. These modeled complexes include both covalently and non-covalently complexed structures. We then performed MD simulations of all the modeled complexes. From the simulations, we can highlight the stability of the complexes, conformational changes, sequence preference, and interactions of the binding pocket residues with different nucleotides. Our work demonstrates that hTOP3B forms stable complexes with both RNA and DNA and highlights the suitability of the complexes for inhibitor discovery and binding study. It also provides a better understanding of the enzyme’s interaction with different nucleic acid substrate sequences.