Bulletin of ANPA

Abstract submitted to ANPA Conference July 14–16, 2023

Volume 5, Number 1

Biological, Medical, Soft Matter and Chemical Physics

Abstract ID: ANPA2023-N00028

Abstract:

ANPA2023-N00028: Dose estimation for muon to develop non-invasive muon method for detection of hypoxia in tumor

Authors:

• Anup Shrestha; Central Department of Physics, Tribhuvan University, Kathmandu, Nepal

• Amba Datt Pant; Institute of Materials Structure Science, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki 305-0801, Japan, Muon Section, Materials and Life Science Division, J-PARC center, 2-4 Shirane Shirakata, Tokai-mura, Naka-gun, Ibaraki 319-1195, Japan

• Hari Shankar Mallik; Central Department of Physics, Tribhuvan University, Kathmandu, Nepal

• Anjan Dahal;

Hypoxia, the region with low oxygen concentration in the tissue[1] is an important factor for tumor treatment. Since hypoxia causes resistance to the treatment [2], its detection is the foremost step towards the treatment process. Even though there are several existing methods to detect hypoxia, they come with limitations due to the requirement of special conditions and mainly due to invasive nature [3-5]. Instead, the newly proposed muon method does not require those special conditions and it is non-invasive in nature too, which is a great advantage over the currently existing methods[3,4]. Muon like a light proton, is more sensitive due to higher magnetic moment. Muonium, a bound state of muon and electron, is like a light isotope of hydrogen atom. In the proposed muon method, muonium undergoes spin exchange interaction with molecular oxygen to provide information about oxygen content in tumor tissue [3]. It is important to find the amount of muon beam dose to be used for the practical applications. Hence, we study the energy, intensity and profile (size) of the beam at various concentrations and sizes of the tumor. The estimated muon beam profile and energy using Monte Carlo simulation will be present in the program. References [1] W. C. Wilson and B. Shapiro, Anesthesiology Clinics of North America, 19 (2001) 769–812. [2] P. Vaupel and L. Harrison, The oncologist, 9 (2004) 4–9. [3] A. D. Pant et. al., Nuclear Instruments and Methods in Physics Research A, 1011 (2021) 165561. [4] A. Pant et. al., Journal of Physics: Conference Series, 551 (2014) 012043. [5] S. Chopra et. al., International journal of radiation biology, 85 (2009) 805–813.

To cite this abstract, use the following reference: https://anpaglobal.org/conference/2023/ANPA2023-N00028